University of Fukui Researcher Information
Faculty of Engineering
Division of Engineering
Materials Science and Engineering
日本語
Update date：2025/05/13
Professor
TOKUNAGA Yuji

University of Fukui Faculty of EngineeringDivision of Engineering Materials Science and Engineering Professor

Education

  1. 1989/03GraduatedTohoku UniversityPharmaceutical Institute薬学科
  2. 1991/03CompletedTohoku University薬学Master
  3. 1989Tohoku University薬学科
  4. 1991Tohoku UniversityGraduate School, Division of Pharmaceutical Sciences薬学専攻Master

Degree

  1. 博士(薬学)

Research History

  1. 1993/04-1996/06東北大学薬学部文部技官
  2. 1996/07-1997/08スクリプス研究所研究員
  3. 1997/08-1999/03大塚製薬研究員

Professional Memberships

  1. アメリカ化学会
  2. 2010-2013日本化学会
  3. 2006-2019/03分子イメージング学会
  4. 2006-2009有機合成化学協会
  5. 2005-2019日本薬学会
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Research Areas

  1. Nanotechnology/MaterialsStructural organic chemistry and physical organic chemistry
  2. Life ScienceBioorganic chemistry

Research Interests

  1. 配位結合、集合体
  2. coordination,assembly
  3. 不斉,水素結合
  4. chirality,hydrogen bond

Subject of Research

  1. 超分子集合体の構築
  2. Construction of supramolecular assembly
  3. 超分子不斉に関する研究
  4. Study on supramolecular chirality

Papers

  1. Synthesis of a cross–chain bridging cryptand2025/03/21T. Yashima, R. Hori, T. Maruyama, K. Nakashima, H. Fujihara, M. Naito, S. Miyagawa, Y. TokunagaOrg. Chem. Front.12, 1754-1762
  2. Entropy-driven formation of a self-assembled molecular capsule through release of amine from ammonium carboxylate salt2024/11/26Yuki Asada, Amane Kobayashi, Masahiro Ueda, Hayato Ban, Masaki Kimura, Masaya Naito, Yuji TokunagaChemistry Letters53/ 11, upae210
  3. Rotaxane Formation from Borate Ion-Containing Crown Ether and Ammonium Ion: Enhancement of Their Association through Ion-Pairing.2024/09/27Takizawa Takumi,Ohtani Kento,Naito Masaya,Miyagawa Shinobu,Tokunaga YujiOrganic letters26/ 38, 8211-821510.1021/acs.orglett.4c032111523-7052We synthesized [2]rotaxanes featuring a catechol borate ion-containing crown ether and secondary ammonium ions. These rotaxane components show both ion-ion interactions and hydrogen bonds. X-ray crystallography and NMR spectroscopy allowed elucidation of the rotaxane structure. Moreover, H NMR spectroscopy revealed the rotaxane synthesis can be thermodynamically controlled. The binding affinity between the borate-containing crown ether and ammonium ions is enhanced by ion-pairing.
  4. Rotational isomerism of amide units in the ring of rotaxanes in response to base/acid stimuli2024/07/25Takanori Nakamura, Yukari Okuma, Shinobu Miyagawa, Tsuneomi Kawasaki, Masaya Naito, Yuji TokunagaChemistry Letters53, upae143
  5. Acid-base responsive molecular switching of a [2]rotaxane incorporating two different stations in an axle component.2024/06/18Yamane Risa,Asai Yuki,Takiguchi Nanami,Okamoto Ayuna,Kawano Shintaro,Tokunaga Yuji,Shizuma Motohiro,Muraoka MasahiroRSC advances14/ 28, 19780-1978610.1039/d4ra03532a2046-2069Interlocked compounds such as rotaxanes and catenanes exhibit unique kinetic properties in response to external chemical or physical stimuli and are therefore expected to be applied to molecular machines and molecular sensors. To develop a novel rotaxane for this application, an isophthalamide macrocycle and a neutral phenanthroline axle were used. Stable pseudorotaxanes are known to be formed using hydrogen bonds and π-π interactions. In this study, we designed a non-symmetric axial molecule and synthesized a [2]rotaxane with the aim of introducing two different stations; a phenanthroline and a secondary amine/ammonium unit. Furthermore, H NMR measurements demonstrated that the obtained rotaxane acts as a molecular switch upon application of external acid/base stimuli.
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Books

  1. 研　究　室　紹　介徳永　雄次オレオサイエンス2015/12
  2. 十字路“ロタキサン・擬ロタキサン”徳永　雄次有機合成化学協会2011/06
  3. ウオータージェット技術徳永　雄次日刊工業新聞2009/04
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Presentations

  1. 三つ葉型アジンの溶媒に依存した光学特性変化日本化学会第 102 春季年会2022/03/25
  2. テトラアミノキノリノポルフィリンとイソフタル酸 2 分子が織り成すアロステリック効果によるダイマー形成2021 年度有機合成化学北陸セミナー2021/09/29
  3. Syntheses of a Helically Chiral [2]Rotaxane and Axially Chiral [2]RotaxanesMolecular chirality Asia 20202020/11/02
  4. 三叉アジンの合成と塩基による段階的な脱プロトン化反応日本化学会 第100春季年会 (2020)2020/03/22
  5. 環状テトラアミドとアンモニウムイオンによるロタキサン合 成、及び擬ロタキサン形成における環サイズ効果日本化学会 第100春季年会 (2020)2020/03/22
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Industrial Property Rights

  1. 光学活性化合物およびその製造方法、光学活性化合物を含む配位化合物、環状化合物、ならびに中間体化合物2020-0265842020/02/1974756382024/04/19
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Awards

  1. 2012/08第10回有機合成化学協会関西支部賞
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Grant-in-Aid for Scientific Research and Health,Labour and Welfare Sciences

  1. 2007新規γ・β線核種によるがん診断・治療の開発研究医療機器開発推進研究事業：ナノメディシン研究
  2. 2007新規γ・β線核種によるがん診断・治療の開発研究医療機器開発推進研究事業：ナノメディシン研究
  3. 2024Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research異なる絡み合い構造を持つ分子の構築と誘発されるトポロジー異性の制御基盤研究(C)（一般）
  4. 2022Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research高次に交差する分子の合成と誘発される分子不斉の高次化Grant-in-Aid for Scientific Research(C)
  5. 2014Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research治療抵抗性うつ病の病態解明・治療法開発に資する分子イメージングプローブの開発基盤研究(B)（一般）
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Contract research

  1. 2003炭素繊維強化アルミニウム基複合材料の開発
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